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KMID : 0882420100780030316
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Korean Journal of Medicine
2010 Volume.78 No. 3 p.316 ~ p.317
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Diagnosis of Clostridium difficile-associated diarrhea
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Chung Doo-Ryeon
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Abstract
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Clostridium difficile-associated diarrhea (CDAD) has been one of common nosocomial infections associated with previous antibiotic use. Early diagnosis and adequate management of CDAD is necessary especially for severe cases, however, diagnosis has not been satisfactory. Cytotoxicity assay or toxigenic culture can be considered as a golden standard for diagnosis of CDAD, however, they are labor intensive and require a long time. Instead, a rapid enzyme immunoassay for toxin A and B has been widely utilized in most clinical laboratories. However, its low sensitivity has also been a limitation. Sigmoidoscopy can be helpful in a rapid diagnosis of CDAD for some cases which show negative results in enzyme immunoassay.
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KEYWORD
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Clostridium difficile, Diarrhea, Colitis, Diagnosis, Sigmoidoscopy
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